I don't think it's an issue,
I've built my 80 gal shallow and it has a few of those, But for a piece of mind scrap off a bit of silicone to get to the bubble and re inject new silicone.
I've used black silicone from lowes the Ge type.
Let it dry good few day's.
Hope this helps
Personally i would remove the panel and redo all the silicone, if u haven't done that before I would reach out to someone that has .
If it leaks and the tank is older the rest of the silicone is not too far behind.
Thats alot of water and pressure on that glass.
My opinion